A £100m redevelopment of 600 hectares of land on the south bank of the River Humber has been given the planning green light by local councillors.
The proposals include the creation of transport depots, warehousing and external storage areas, offices, a business park and motel.
There will be road and rail links to the nearby port of Immingham and the Humber Sea Terminal.
The planning application by Able UK will now go forward for approval by Communities Secretary Eric Pickles.
Councillor Mark Kirk, leader of North Lincolnshire Council, said: “Without a doubt this is the largest application ever presented to this council that will create thousands of jobs for local people.
“The decision today marks a significant step in realising the enormous economic potential of the South Humber Gateway.”