In partnership with One Housing, Mulalley will build 491 new homes, a new community centre and more than 3,000 sq m of commercial space, along with associated public and highway improvements.
The development team was appointed by Enfield borough council.
A planning application is now be prepared by Mulalley and One Housing with the former Sir John Lawrence pub as the first site to be developed.
Building will start in early 2012 and the first properties will become available in 2014.
The development meets Enfield council’s core strategy requirements of providing 60% private and 40% affordable housing. Almost 100 new family sized dwellings will be provided.
Cllr Del Goddard, cabinet member for business and regeneration, said; "The regeneration of Ladderswood is the first major flagship project for Enfield Council, and the appointment of Mulalley and One Housing marks an important milestone for the project.
Cllr Ahmet Oykener, cabinet member for housing, said; "Ladderswood is the first of several estate renewal programmes that the council is leading on. This development will provide new, sustainable housing for Enfield residents and will increase the supply of affordable housing in the borough, in particular increasing the supply of family-sized housing."