Barratt Homes and Miller Homes have signed up to build the first 177 homes and, subject to detailed planning consent, will start on site in August.
The scheme has been in planning stages for more than 10 years. Urban regeneration specialist Sigma has led planning and commercial negotiations as development manager on behalf of Regenco Trading Ltd since 2010.
The Winchburgh development, eight miles from Edinburgh, covers approximately 350 hectares (870 acres). It is one of the UK's single largest residential and mixed use developments, worth an estimated £1bn in total. The masterplan includes the construction of approximately 3,500 new homes, five new schools, a town centre, town park, retail facilities and a commercial park, as well as associated rail and road infrastructure, including a new motorway junction, train station and park & ride facilities.
Sigma CEO Graham Barnet said: "The granting of planning permission in principle by West Lothian Council for the Winchburgh development masterplan unlocks the development of this substantial site. We are delighted to have reached this landmark and will be supporting the next stage, which involves the early delivery of 177 new homes."