The Lightbox, designed by AHR, is a 19-storey development of 238 apartments for private sale.
Completion of the scheme is expected in the first quarter of 2019.
Bouygues UK chief operating officer Craig Tatton said: “Securing this scheme in the northwest is a fantastic achievement and Lightbox is an exciting project. Greater Manchester is a core focus for us as we look to apply the technical expertise we have as part of the wider Bouygues group to major projects where we can add value.”
Stephen Wild, managing director of MediaCityUK said: “We are very proud of what we have achieved here at MediaCityUK so far, and Lightbox will bring a new residential community to what is already a thriving and vibrant destination.”