Ministers have agreed with a compulsory purchase order (CPO) made by the London Borough of Haringey, which will enable the project to go ahead.
Building a new 56,000-seater stadium next door to its current White Hart Lane home is part of a wider regeneration plan for the area – the £400m Northumberland Development Project.
More than 95% of the three hectare site has already been acquired by agreement and work has already begun on the first of three phases of the redevelopment plan. The order was requested to allow the final two phases to proceed and follows a public inquiry.
Communities secretary Eric Pickles said: “This scheme is supported by the locally determined development plan for the area and has received strong local support.
“The redevelopment proposals have had far reaching support from local MPs, the London Mayor’s champion for Tottenham and the chairman of the Independent Tottenham Taskforce.
“They all consider the project important for bringing much needed private investment into one of the most disadvantaged areas of London.”