Birmingham City Council has given approval to the final phases of the £200m Beorma Quarter development designed by architect Broadway for property group Salhia Investments.
The proposals include a 30-storey mixed-use tower with retail space, 155,000 sq ft of office space and 125 apartments.
Also proposed are a seven-storey office building and a 13-storey apartment building. At the heart of the development is to be a new public square called Orwell Place.
The first phase of the scheme was completed earlier this year. This included the refurbishment of the former Bullring Markets Coldstore building into an office complex and innovation centre as well as the development of a new Adagio hotel.
Broadway Malyan director Neil Rose said: “This scheme will be on the doorstep of the proposed HS2 station and we believe it will not only provide a suitable backdrop for such an important gateway to the city but will be a popular location for occupiers and residents who want easy access to this international rail hub.”