The project includes an 80-bed Travelodge hotel, 20,000-square-foot of retail space and 50 serviced apartments.
The development for LPC Living is being built on the site of the former Gibbons furniture store next to Hackney Central station.
Completion is scheduled for spring 2014.
Anglo Holt Construction managing director Andy Elwell said: “We have a successful 12-year partnership with Travelodge so we are proud to be involved with building its first hotel in Hackney.”
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