The Homes and Communities Agency has insisted it its "business as usual" despite the departure of its chief executive Sir Bob Kerslake, who has been appointed permanent secretary at the Department for Communities and Local Government.
It is the highest civil servant post in the department.
Kerslake will take up his new post on 1 November. The HCA will initially appoint a new interim chief executive from its existing group of directors.
HCA chairman Robert Napier said he was sorry to lose Kerslake: "Bob has literally lived and breathed the HCA since he was appointed just over two years ago, and along with the hard work and commitment of all our staff he has played a major part in our success to date."
"Looking forward we have a continuing and evolving role, as well as a business to run as usual, and over the coming months we will continue to deliver against our current programmes while we shape our new way for doing business."
"I am pleased that Government recognises that the key role that the HCA has to play in helping to shape local places, and that our staff have the necessary skills and expertise to adapt to our changing world."