The gross development value is estimated at £275m.
The 8.9 acre site in the Royal Borough of Greenwich has 130m of river frontage between the O2 Arena and Greenwich town centre.
In addition to new homes, the Enderby Wharf site has detailed planning permission for a cruise ship terminal, a 250-room hotel, commercial space and the restoration of the Grade II listed Enderby House that was built in the 1830s.
Barratt London will start construction of the residential elements, including 154 affordable homes, this autumn. As with its other London JVs, Barratt London will provide construction, development, accountancy and sales services to the JV.
Morgan Stanley Real Estate Investing will work with West Properties to deliver the cruise terminal and hotel.
The site was first developed by the whaling company Enderby & Sons in the 18th century. Subsequently it was used to manufacture some of the first transatlantic telecommunications cables and a cross-channel petrol pipeline to support the D-Day invasion.
Barratt London regional managing director Alastair Baird said: “Our London business is expanding built on our capability to deliver challenging projects on time. This is a first class riverside site and we look forward to working with all the local stakeholders to deliver desperately needed homes and local facilities that will regenerate this important site. We have an outstanding track record of delivery and we will be on site as soon as possible.”
Greenwich council leader Chris Roberts said: “We’re hugely proud of the rich mix of attractions, culture and history we have at the World Heritage site and beyond in Greenwich – and of course of our proud maritime history. The construction of London’s first cruise terminal at Enderby Wharf, as a direct result of this investment, will be a big landmark in that history and a superb addition to all we have to offer here in Royal Greenwich."