The Y Towers, which will be 110m and 102m tall, will be built in Overhoeks, across the canal from the railway station.
The taller of the two towers is for a hotel of 579 rooms while the other is for residential use.
At the base of the two towers there will be a shared four-storey podium that will house a congress centre, an auditorium, gyms, a spa, restaurants and offices.
There will also be two levels of underground parking for public use.
Landscaping will be a particular feature, with large green areas, cycle paths and access to the complex via water.
Moritsch Cranes has a deal to supply four new luffing tower cranes for the project – RTL 285 and RTL 325 models up to 129 metres.
The completion of the works is scheduled for December 2022.