The ‘Gateway Project’ will provide a distinctive entrance to the campus from Salford Crescent railway station.
Designers have targeted a BREEAM rating of ‘excellent’ for the building.
Completion is set for early 2016.
Construction of the seven-storey building, designed by architect Stride Treglown, was originally scheduled to begin in early 2012 and be complete by April 2014. Planning permission was granted two years ago. At that time the project cost was estimated at £35m.
The investment is part of wider plans to improve the campus. Last year the University refurbished and extended its 1960s Chapman Building at a cost of £9m. During the summer a further £1m was spent improving library services.