The primary focus is on high-risk activity such as working at height, but inspectors will also be pushing for sites to be clean and tidy with clear access routes.
The campaign runs from 20 February to 16 March.
HSE chief inspector of construction Philip White said: "The refurbishment sector continues to be the most risky for construction workers, all too often straightforward practical precautions are not considered and workers are put at risk. In many cases simple changes to working practices can make all the difference.
"Poor management of risks in this industry is unacceptable. As we have demonstrated in the past, we will take strong action if we find evidence that workers are being unnecessarily put at risk."
During 2010/11, 50 workers were killed while working in construction and 2,298 major injuries were reported.