Under the plans, Kier Property can develop 10 acres into 179 new homes, 19,000 sq ft of office space and 15,000 sq ft of retail including shops, a restaurant and a pub.
Kier has already developed part of the 24-acre former OS site, which was acquired in 2010 as part of a deal to develop a new headquarters for the mapping giant at Adanac Park.
The £3.4m refurbishment of Compass House has created office space, which is now home to a number of businesses. There is still 22,740sq ft still available to let with 76 parking spaces.
On the 11-acre western part of the site, Taylor Wimpey has started work on 193 new homes.
Kier Property director Kevin Dixon said: “We are delighted that outline planning permission has been granted on a unanimous basis for the Romsey Road development. The new homes, offices and retail outlets planned for the site will compliment the office space that has already been developed at Compass House, bringing new business into the city and regenerating the whole area.”