Work on the first projects is due to start on site in July 2014 with the overall programme of works continuing until at least 2018.
Under the ProCure21+ framework, work will include refurbishment, extension and new build projects, ranging in value from £1m to £20m. Kier's work will support the integration of health and care services at City General Hospital in Stoke and Stafford Hospital.
More specifically, initial projects will include building a new critical care unit, operating theatres and imaging facilities, as well as refurbishing existing inpatient wards and constructing new ones in order to increase the number of available beds.
Kier said that it was aiming to select 70% of the labour, subcontractors and materials suppliers from the surrounding area and to support more than 100 building trade apprenticeships on the programme.
Kier finance director Haydn Mursell said: "We have extensive healthcare experience in the delivery of acute, mental health and community facilities and we are looking forward to working collaboratively with the Trust to deliver outstanding new healthcare facilities for Staffordshire. ProCure 21+, like other strategic frameworks, provides a pipeline of opportunities. Over the last 11 years, we have secured over 130 projects through ProCure 21 and ProCure 21+, worth over £1.1bn to the group.
"Today's announcement brings the total new awards to Kier under frameworks to over £400m since 31 December 2013."