The tribunal had earlier found builders merchant Jewson guilty of discrimination when it sacked a long-serving manager five months after he had a stroke.
Jonathan Jones, 57, was branch manager for Jewson in Cardigan, West Wales, and had worked for the company for 22 years when he suffered a stroke on 25 April 2009.
After five months sick leave, Jewson dismissed him.
The compensation award of £390,870 for Mr Jones is short of the £1m that his solicitor was seeking but way ahead of the £57,206 was offering. It is also believed to be one of the largest pay-outs ever made for disability discrimination.
Mr Jones’ solicitor, Stephen Jackson of Cardiff-based Jackson Osborne Employment Lawyers, told the Western Mail: “I am very pleased for Mr Jones. He has had to endure tactics of delay, unfounded allegations and obstruction. He has lost his career after 21 years of service working, as the tribunal accepted, more than 60 hours a week without taking holidays. For a company which is part of a £20bn turnover, the whole affair was handled very badly.”