Wates will be working on the project with architect Pringle Brandon Perkins+Will, building services consultant Hilson Moran and structural engineer Mott MacDonald.
Contract value has been reported at around £14m.
The building, called One The Square, will comprise 129,295 sq ft of office space and 13,379 sq ft of retail space.
Wates is now preparing the site, with main preliminary works carried out over a 47-week programme. Construction on the new building is scheduled to begin in February 2015, with project completion expected for the end of 2016.
The scheme will be built alongside Abellio Greater Anglia’s work to redesign Cambridge train station, including an enlarged ticket hall and improved customer service facilities.
One The Square forms part of Brookgate’s wider CB1 masterplan to regenerate Cambridge city centre. The programme comprises the creation of a mixed-use development of commercial, leisure and residential spaces alongside new public spaces and improvements to the public transport. Also included in the scheme is the city’s largest student accommodation development for a decade and 21 Station Road, now home to Microsoft Research’s new HQ, both of which have been built by Wates.
The contractor is also currently delivering the new 22 Station Road office development, a five-storey complex that will become the headquarters of consulting engineer Mott MacDonald.
Wates Construction regional director Phil Shortman said: “The ongoing development of Cambridge city centre is an incredible achievement and Wates is proud to be playing such a key part in the delivery of the CB1 masterplan.”
Brookgate chief executive Sven Topel said: “We are very excited to have reached this next stage of the masterplan. One the Square is a key element of CB1 as it not only delivers a new office and leisure space at the main gateway to the city but also provides public realm and transport improvements, which will create a buzzing hub around the train station.”